ࡱ> ` Pbjbjss4*%*8*8*8*8*8*8*8>8FdFdFd8~d4d\>8Bff"8>8>8$bO>8>8>8bO>8>8>8*8*8*8*8*8*8 STROBE Statementchecklist of items that should be included in reports of observational studies Item NoRecommendationTitle and abstract1(a) Indicate the studys design with a commonly used term in the title or the abstract(b) Provide in the abstract an informative and balanced summary of what was done and what was foundIntroductionBackground/rationale2Explain the scientific background and rationale for the investigation being reportedObjectives3State specific objectives, including any prespecified hypothesesMethodsStudy design4Present key elements of study design early in the paperSetting5Describe the setting, locations, and relevant dates, including periods of recruitment, exposure, follow-up, and data collectionParticipants6(a) Cohort studyGive the eligibility criteria, and the sources and methods of selection of participants. Describe methods of follow-up Case-control studyGive the eligibility criteria, and the sources and methods of case ascertainment and control selection. Give the rationale for the choice of cases and controls Cross-sectional studyGive the eligibility criteria, and the sources and methods of selection of participants(b) Cohort studyFor matched studies, give matching criteria and number of exposed and unexposed Case-control studyFor matched studies, give matching criteria and the number of controls per caseVariables7Clearly define all outcomes, exposures, predictors, potential confounders, and effect modifiers. Give diagnostic criteria, if applicableData sources/ measurement8* For each variable of interest, give sources of data and details of methods of assessment (measurement). Describe comparability of assessment methods if there is more than one groupBias9Describe any efforts to address potential sources of biasStudy size10Explain how the study size was arrived atQuantitative variables11Explain how quantitative variables were handled in the analyses. If applicable, describe which groupings were chosen and whyStatistical methods12(a) Describe all statistical methods, including those used to control for confounding(b) Describe any methods used to examine subgroups and interactions(c) Explain how missing data were addressed(d) Cohort studyIf applicable, explain how loss to follow-up was addressed Case-control studyIf applicable, explain how matching of cases and controls was addressed Cross-sectional studyIf applicable, describe analytical methods taking account of sampling strategy(e) Describe any sensitivity analysesContinued on next page ResultsParticipants13*(a) Report numbers of individuals at each stage of studyeg numbers potentially eligible, examined for eligibility, confirmed eligible, included in the study, completing follow-up, and analysed(b) Give reasons for non-participation at each stage(c) Consider use of a flow diagramDescriptive data14*(a) Give characteristics of study participants (eg demographic, clinical, social) and information on exposures and potential confounders(b) Indicate number of participants with missing data for each variable of interest(c) Cohort studySummarise follow-up time (eg, average and total amount)Outcome data15*Cohort studyReport numbers of outcome events or summary measures over timeCase-control studyReport numbers in each exposure category, or summary measures of exposureCross-sectional studyReport numbers of outcome events or summary measuresMain results16(a) Give unadjusted estimates and, if applicable, confounder-adjusted estimates and their precision (eg, 95% confidence interval). Make clear which confounders were adjusted for and why they were included(b) Report category boundaries when continuous variables were categorized(c) If relevant, consider translating estimates of relative risk into absolute risk for a meaningful time periodOther analyses17Report other analyses doneeg analyses of subgroups and interactions, and sensitivity analysesDiscussionKey results18Summarise key results with reference to study objectivesLimitations19Discuss limitations of the study, taking into account sources of potential bias or imprecision. Discuss both direction and magnitude of any potential biasInterpretation20Give a cautious overall interpretation of results considering objectives, limitations, multiplicity of analyses, results from similar studies, and other relevant evidenceGeneralisability21Discuss the generalisability (external validity) of the study resultsOther informationFunding22Give the source of funding and the role of the funders for the present study and, if applicable, for the original study on which the present article is based *Give information separately for cases and controls in case-control studies and, if applicable, for exposed and unexposed groups in cohort and cross-sectional studies. Note: An Explanation and Elaboration article discusses each checklist item and gives methodological background and published examples of transparent reporting. The STROBE checklist is best used in conjunction with this article (freely available on the Web sites of PLoS Medicine at http://www.plosmedicine.org/, Annals of Internal Medicine at http://www.annals.org/, and Epidemiology at http://www.epidem.com/). Information on the STROBE Initiative is available at www.strobe-statement.org.     PAGE  PAGE 2 3<@_`abyzN Z \ q   ! . i q      > M S ƼzphJU"hlCJ\ h2J6CJhJU"hzCJhJU"h6cfCJhJU"ho CJ\hJU"ho 6CJhJU"ho CJh&ho 5CJ\h&h&5CJhJU"h)!7CJhJU"hDPCJ\hJU"hDPCJ h*e?h2Jhzh2Jhh*u h*e?hz,`abjyz@kd$$IfF &06    44 la$ $Ifa$gdJU"l  $IfgdJU"l !egd}V[*OzD- $IfgdJU"l kd$$If4F &``06    44 la$ $Ifa$gdJU"l  $IfgdJU"l M N [ D- $IfgdJU"l kd/$$If4F &  06    44 la $IfgdJU"l $ $Ifa$gdJU"l [ \ q s k$ $Ifa$gdJU"l  $IfgdJU"l bkd$$If&0644 la  v_E_$ $Ifa$gdJU"l  $IfgdJU"l kd<$$IfF &06    44 la  v_ $IfgdJU"l kd$$IfF &06    44 la ! . 0 h kT $IfgdJU"l $ $Ifa$gdJU"l  $IfgdJU"l bkdX$$If&0644 lah i q s v_E. $IfgdJU"l $ $Ifa$gdJU"l  $IfgdJU"l kd$$IfF &06    44 la   > v_E.. $IfgdJU"l $ $Ifa$gdJU"l T $IfgdJU"l TkdX$$IfF &06    44 la>  ^G-$ $Ifa$gdJU"l T $IfgdJU"l Tkd$$If4F &``06    44 la $IfgdJU"l   " r s t ~   $%&'( +Yp  _`¹sf\\\hJU"h|@CJ\hJU"h|@B*CJphhJU"h|@B*CJ\phhJU"hB6CJ hCJ\hJU"h)CJ\hJU"h)CJhJU"hzCJhJU"hzCJ\hJU"h)!7CJhJU"hl6CJhJU"h|@6CJ\hJU"h|@5CJ\hJU"h|@6CJhJU"h|@CJhJU"hlCJ$ s t ~ ^G-G$ $Ifa$gdJU"l  $IfgdJU"l kd$$If4F &  06    44 la $IfgdJU"l T  $'v_E_$ $Ifa$gdJU"l T $IfgdJU"l Tkd$$IfF &06    44 lat]C, $IfgdJU"l $ $Ifa$gdJU"l  $IfgdJU"l kd$$If&F &06    44 la +.Xv_E. $IfgdJU"l $ $Ifa$gdJU"l  $IfgdJU"l kd<$$IfF &06    44 laXYpsv_E. $IfgdJU"l $ $Ifa$gdJU"l T $IfgdJU"l Tkd$$IfF &06    44 la^v_E. $IfgdJU"l $ $Ifa$gdJU"l  $IfgdJU"l kdX$$IfF &06    44 la^_`au^D- $IfgdJU"l $ $Ifa$gdJU"l  $IfgdJU"l kd$$If4F &``06    44 la`bc#5~ %,.;=>?C9:;<@_`klqstuyhJU"h6cfCJ\hJU"h)!7CJ h&CJhJU"hzCJ\hJU"hzCJhJU"h6cfCJh2Jh2JCJaJhJU"h|@6>*CJh2J6CJ\hJU"h|@6CJ\hJU"h|@CJ\hJU"h|@6CJhJU"h|@CJ3u^D- $IfgdJU"l $ $Ifa$gdJU"l T $IfgdJU"l Tkd $$If4F &  06    44 la#~u^D-- $IfgdJU"l $ $Ifa$gdJU"l  $IfgdJU"l kd $$If4F &  06    44 la~ ^G-$ $Ifa$gdJU"l  $IfgdJU"l kd $$If4F &  06    44 la $IfgdJU"l   %-us\ $IfgdJU"l kdR $$If4F &  06    44 la-.;?k$ $Ifa$gdJU"l  $IfgdJU"l bkd $$If&0644 la9u^D^$ $Ifa$gdJU"l  $IfgdJU"l kd_ $$If4Fuy&``06    44 la9:;<_u^D^$ $Ifa$gdJU"l T $IfgdJU"l Tkd $$If4Fuy&  06    44 la_`quu^D^$ $Ifa$gdJU"l  $IfgdJU"l kd $$If4Fuy&  06    44 laUu^D^$ $Ifa$gdJU"l  $IfgdJU"l kd0$$If4Fuy&``06    44 laUVWX\h^_`abqxKLM\ʹʯhIah|@CJhIahIaCJhJU"h|@6CJhJU"h|@CJhJU"h|@CJ\ h2J6CJhJU"hl6CJhJU"hlCJhJU"hlCJ\hJU"h)!7CJ h&CJhJU"hzCJhJU"hzCJ\5UVWXu^D^$ $Ifa$gdJU"l T $IfgdJU"l Tkd$$If4Fuy&  06    44 lau^D^$ $Ifa$gdJU"l  $IfgdJU"l kdf$$If4Fuy&  06    44 la_s\B\$ $Ifa$gdJU"l  $IfgdJU"l kd$$If4'Fuy&``06    44 la_`abs\B\$ $Ifa$gdJU"l  $IfgdJU"l kd$$If4&Fuy&  06    44 las\B+ $IfgdJU"l $ $Ifa$gdJU"l T $IfgdJU"l Tkd?$$If4&Fuy&  06    44 lau^D- $IfgdJU"l $ $Ifa$gdJU"l  $IfgdJU"l kd$$If4Fuy&``06    44 laLu^D- $IfgdJU"l $ $Ifa$gdJU"l  $IfgdJU"l kdy$$If4Fuy&  06    44 laLM\_u^D^$ $Ifa$gdJU"l T $IfgdJU"l Tkd$$If4Fuy&  06    44 lav_ $IfgdJU"l kd$$IfFuy&06    44 la }%4>?D)*+-.013467=>?ABHI}}y}h< h<0Jjh<0JUh#jh#Uh&hR#CJh&h&CJh{h&5CJ hW,CJ h2JCJ h&CJ\hJU"h)!7CJhJU"hzCJ\hJU"h|@CJhJU"h|@CJ\hJU"hzCJhJU"h6cfCJ+kT $IfgdJU"l $ $Ifa$gdJU"l  $IfgdJU"l bkd=$$If&0644 la #v_E. $IfgdJU"l $ $Ifa$gdJU"l T $IfgdJU"l Tkd$$IfFuy&06    44 la|v_E. $IfgdJU"l $ $Ifa$gdJU"l  $IfgdJU"l kd=$$IfFuy&06    44 la|}v_E. $IfgdJU"l $ $Ifa$gdJU"l  $IfgdJU"l kd$$IfFuy&06    44 lav_ $IfgdJU"l kdY$$IfFuy&06    44 lak$ $Ifa$gdJU"l  $IfgdJU"l bkd$$If&0644 la>?*,-/023vmmmdbbbbbbc gd&c gdJU"kdY$$IfFuy&06    44 la 356?@ALMNOPc gd& &`#$gdh]hgd ] &`#$gd< IJKLNOPh&hR#CJh#h< h<0Jjh<0JUhIa0JmHnHu21h:p&. A!n"n#n$n% $$If!vh5X55J#vX#v#vJ:V 06,5$$If!vh5X55J#vX#v#vJ:V 406++5$$If!vh5X55J#vX#v#vJ:V 406++5p$$If!vh5&#v&:V 065$$If!vh5X55J#vX#v#vJ:V 065$$If!vh5X55J#vX#v#vJ:V 065p$$If!vh5&#v&:V 065$$If!vh5X55J#vX#v#vJ:V 065$$If!vh5X55J#vX#v#vJ:V 065$$If!vh5X55J#vX#v#vJ:V 406++5$$If!vh5X55J#vX#v#vJ:V 406++5$$If!vh5X55J#vX#v#vJ:V 065$$If!vh5X55J#vX#v#vJ:V &065$$If!vh5X55J#vX#v#vJ:V 065$$If!vh5X55J#vX#v#vJ:V 065$$If!vh5X55J#vX#v#vJ:V 065$$If!vh5X55J#vX#v#vJ:V 406++5$$If!vh5X55J#vX#v#vJ:V 406++5$$If!vh5X55J#vX#v#vJ:V 406++5$$If!vh5X55J#vX#v#vJ:V 406++5$$If!vh5X55J#vX#v#vJ:V 406++5p$$If!vh5&#v&:V 065$$If!vh555#v#v#v:V 406++5$$If!vh555#v#v#v:V 406++5$$If!vh555#v#v#v:V 406++5$$If!vh555#v#v#v:V 406++5$$If!vh555#v#v#v:V 406++5$$If!vh555#v#v#v:V 406++5$$If!vh555#v#v#v:V 4'06++5$$If!vh555#v#v#v:V 4&06++5$$If!vh555#v#v#v:V 4&06++5$$If!vh555#v#v#v:V 406++5$$If!vh555#v#v#v:V 406++5$$If!vh555#v#v#v:V 406++5$$If!vh555#v#v#v:V 065p$$If!vh5&#v&:V 065$$If!vh555#v#v#v:V 065$$If!vh555#v#v#v:V 065$$If!vh555#v#v#v:V 065$$If!vh555#v#v#v:V 065p$$If!vh5&#v&:V 065$$If!vh555#v#v#v:V 065F@F o StandarddCJ_HmH sH tH ^@^ o berschrift 1$<@&5CJ KH OJQJ\aJ `@` o berschrift 2$ & Fd<@&56OJQJZ@Z o berschrift 3$ & Fd<@&OJQJ^@^ o berschrift 4$ & Fd<@& 5OJQJR@R o berschrift 5 & Fd<@&CJV@V o berschrift 6 & Fd<@&6CJZ@Z o berschrift 7 & Fd<@& CJOJQJ^@^ o berschrift 8 & Fd<@&6CJOJQJ` @` o berschrift 9 & Fd<@&56CJOJQJJA@J o Absatz-Standardschriftart`i@` 6cfNormale Tabelle :V 44 la PJ0k0o Keine Liste VC@V o Textkrper-Zeileneinzugx^PP ["SprechblasentextCJOJQJ^JaJJ @J o Fuzeile 9r d CJOJQJ,)@!, o SeitenzahlD@2D o Kopfzeile 9r dCJ>B> o FunotentextdCJ6OqR6 o AmendmentNote8Z@b8 o Nur Text CJOJQJ<Or< o Abbreviationsd:O: o AbstractParadLOL o AbstractTitledx@&5CJ6O6 o Accepted dx8O8 o Acknowledged8O8 o Address dP52O2 o Author dP6O6 o AuthoredByd:O: o Banner dx6CJTOT o BoxEnd. dx&d 'd P Q VOV o BoxStart1*!d$d %d N O .O". o BoxStart2".O2. o BoxStart3#J"@J o Beschriftung$dxx5CJ@R@ o Kommentartext%dCJBT@bB o Blocktext&x]^:Or: o Conflict'dxx8O8 o Correspdent(d,OA, o Credit)CJ,L@, o Datum*dXOXo Article+$dx<*$5CJOJQJmHnHu2O2 o Para, dh` 8O8 o EdFtNote-<`4B@4 o Textkrper.x:*: o EndnotenzeichenH*>+> o Endnotentext0dCJLOL o IndentQuote1  d<] ^ ,O", o Epigraph28O28 o Equation3d56.OB. o FigLeg4dNORN o Figure#5 & F p^`56Oa6 o FigureRef B*H*ph4Oq4 o FnoteRef B*H*ph2O2 o Footnote8d:&: o FunotenzeichenH*4O4 o Funding :dx0O0 o GroupTitle;>O> o HeadA<$dx*$@&5BOB o HeadB=$d<*$@&5CJBOB o HeadC>$d<*$@&6CJ>P@> o Textkrper 2 ?dx2O2 o Keywords@dN0@N o AufzhlungszeichenA & F d4O"4 o List1Bd(x8O28 o List2Cd(^@Q@B@ o Textkrper 3DxCJaJ:OR: o ListParaEd^@Ob@ o Miscellaneous Fdx6Or6 o MoreInfo Gdx<O< o MoreInfoWeb Hdx:>@: o Titel I<<@&5CJ,O, o Noindexphf2O2 o ParaContKdh,O, o HeadEL56>O> o Participators Mxx6X@6 o Hervorhebung6]8O8 o GroupAuthorO56<'< o KommentarzeichenCJ6O6 o PositionQd62O"2 o ProductAuthR8O28 o ProductDetailsSZM@BZ o Textkrper-Erstzeileneinzug T`0OR0 o QuoteRefU<0Ob0 o Rating V`POrP o Reference#W & FSdh(^`S.O. o RelatedToX4O4 o RelatedToWebY,O, o ReviewedZ(K@( o Anrede[6O6 o ShortAuthor\6@O@ o ShortTitle]6CJOJQJ6O6 o SourceRef ^`0O0 o Standfirst_<J@< o Untertitel `<@&6,O, o SubTitlea<O"< o Tableb & F 6.O2. o TableNotec4OA4 o TableRef B*H*ph0OR0 o TableTitlee<Ob< o Topic fd( 6B*ph(Oq( o URL B*phffBOB o WebRefh & F h^h,O, o XRef B*H*ph^N@^ o Textkrper-Erstzeileneinzug 2 j`"O" o wXRef"Or" o email.O. o BoxStartxm.O. o HeadDn@&CJTR@T o Textkrper-Einzug 2odx^VS@V o Textkrper-Einzug 3px^CJaJ8?@8 o Gruformel q^ZY"Z o Dokumentstrukturr-D M OJQJ^J:[@2: o E-Mail-Signatursf$@Bf o Umschlagadresse!t@ &+D/^@ OJQJaJV%@RV o Umschlagabsenderadresseu CJOJQJHV@aH o BesuchterHyperlink >*B* ph0_@q0 o HTML Akronym:`@: o HTML Adressex6]2a@2 o HTML Zitat6]:b@: o HTML CodeCJOJQJaJ<c@< o HTML Definition6]Bd@B o HTML TastaturCJOJQJaJLe@L o HTML Vorformatiert} CJOJQJ:f@: o HTML BeispielOJQJPg@P o HTML SchreibmaschineCJOJQJaJ8h@8 o HTML Variable6]6U@6 o Hyperlink >*B*ph: @: o Index 1^`: : o Index 2^`: : o Index 3^`: : o Index 4^`:: o Index 5^`:: o Index 6^`:: o Index 7^`:: o Index 8^`:: o Index 9p^p`J!"J o Indexberschrift5OJQJ\0(@0 o Zeilennummer6/@6 o Liste^`:2@: o Liste 26^6`:3@: o Liste 3Q^Q`:4@ : o Liste 4l^l`:5@ : o Liste 5^`L6@" L o Aufzhlungszeichen 2 & F L7@2 L o Aufzhlungszeichen 3 & F L8@B L o Aufzhlungszeichen 4 & F L9@R L o Aufzhlungszeichen 5 & FJD@b J o Listenfortsetzungx^NE@r N o Listenfortsetzung 26x^6NF@ N o Listenfortsetzung 3Qx^QNG@ N o Listenfortsetzung 4lx^lNH@ N o Listenfortsetzung 5x^<1@ < o Listennummer & F@:@ @ o Listennummer 2 & F@;@ @ o Listennummer 3 & F@<@ @ o Listennummer 4 & F@=@ @ o Listennummer 5 & Fl- l o Makrotext(  ` @ dOJQJ_HmH sH tH I@ o Nachrichtenkopfgn$d%d&d'd-DM NOPQ^n` OJQJaJ<^@" < o Standard (Web)aJ@@2 @ o Standardeinzug ^LO@L o Fu/-EndnotenberschriftTOQ T o ParaHead+B*ehfHphq rHOb H o ObitBiogdx` 56CJHOr H o TableHeaderdx`5.O . o Image 5B*ph4Oq 4 o TableSubHead0O 0o ArtGroupCJ$Oq $ o Biog:O : o SearchInfo dx:O : o SeriesInfo dx2O 2 o Remark B*ph.O1 . o BoxStart4<Oq < o Bibliography & F.O . o PullQuote0O" 0 o AncillHead*O2 * o RefHeadDOB D o FlushQuote]^CJ<O"< o ProductTitle5CJ:Ob : o EthicalApproval0Or 0 6cf Abrv-Title,O , 6cfWeb logo0O 0 6cf Preformatted<O < 6cfAuxillary Number"O " 6cfDOI*O * 6cfUnit-ID4O 4 6cf Abbreviation0O 0 6cfAppendix5:O : 6cf Authored by5CJ2O 2 6cf BookDetails,O , 6cfBoxStart,O" , 6cfCitation6O2 6 6cf Correspondent4OB 4 6cf EquationText.OR . 6cf Footnotes,Ob , 6cfKeyWords4Or 4 6cf ListParaMore2O 2 6cf Onlinefirst2O 2 6cfQuote ^CJ,O , 6cfReceived0O 0 6cfRelated562O 2 6cf RespTitle54O 4 6cf ShortAuthorsDO D 6cfTable Footnote CJOJQJ0O 0 6cfTopic(s)6*O * 6cfRevised2O 2 6cf Table Width0O" 0 6cf Table FontFO2 F 6cf Article Title5CJ$OJQJ@OB @ 6cf BNF Number5CJOJQJ@OR @ 6cf Introduction CJOJQJ:Ob : 6cf Paragraph CJOJQJ@Or @ 6cf Table Head5CJOJQJ<O < 6cf Table Body CJOJQJDO D 6cfFigure Caption CJOJQJ<O < 6cf References CJOJQJDjQRD xKommentarthemad5\P`abjyzMN[\qs !.0hiqs>st~  $' +.XYps^_`a# ~ % - . ; ?     9 : ; < _ ` q u  U V W X   _ ` a b LM\_ #|}>?*,-/02356?@ALMNQe0e00 0 0 0 @0 @0 @0 @0 `0 `0 @0 @0 @0 @0 @0 @0 @0 @0 @0 @0 @0 @0 @0 @0 @0 @0 @0 @0 @0 @0 @0 @0 @0 @0 @0@0@0 @0 `0 `0 @0@0 @0 @0 @0 @0 @0 @0 @0 @0 @0 @0 @0 @0 @0 @0 @0 @0 @0 @0 @0 @0 @0 @0 @0 @0 @0 `0 `0 @0 @0 `0 `0 @0 @0 `0 `0 @0@0@0 @0 0 0 0 0 00 0 @0 @0 @0 @0 `0 `0 @0 @0 `0 `0 @0 @0 0 0 0 0 `0 `0 @0 @0 `0 `0 @0 @0 @0 @0 @0 @0 `0 `0 @0 @0 `0 `0 @0 @0 @0 @0 0 @0 `0 `0 @0 @0 `0 `0 0 @0 0 0 0 0 0 0 @0 @0 @0 @0 @0 @0 @0 @0 @0 @0 @0 @0 @0 @0 @0 @0 0 0 @0 @0 @0 @0 c0c0c0c0@0h00@0h00@0h00@0h00@0@0@0@0@0@0h00,$abjyzMN[\qs !.0hiqs>st~  $' +.XYps^_`a# ~ - . ; ?     9 : ; < _ ` q u  U V W X   _ ` a b LM\_ #|}>?Qe0@0@0@0@0@0@0@0@0`0`0@0@0@0@0@0@0@0@0@0@0@0@0@0@0@0@000 @0@0@000 @0@0@00"00"00"0 @0`0`0@0@0@0@0@0@0@0@0@0@0@0@0@0060 @0@0@00:0 @0@0@00>0 @0@0@00C0 @0`0`00H0 @0`0`00L0 @0`0`00P00P00P0 @0`0`00V0 @0@0@0@0 @0 @0 @0`0`0@0 @0`0`0@0 @0 @0 @0 @0 @0 `0 `0@0 @0 `0 `0 @0 @0@0@0@0 @0 `0 `0 @0 @0 `0 `0 @0 @0 @0@00\0 @0 `0 `0 0`0 @0 `0 `0 0d0 @0@0@0@0@0@0@0@0 @0 00 @0@0@000 @0@0@000 @0@0@000 @0@0@0@0@0@0@0c0 0 $$$' `IP#-7@z[  h >  X^~ -9_U_L|3P !"$%&'()*+,./012345689:;<=>?O  '!!8@0(  B S  ?bbold1italic1bold2italic2bold3italic3bold4italic4italic5bold5italic6bold6italic7bold7italic8bold8italic9bold9italic10bold10italic11bold11italic12bold12italic13bold13italic14bold14italic15bold16italic17bold17italic18bold18italic19bold19bold20italic20bold21italic21bold22italic22bold23italic23italic24italic25bold24italic26bold25italic27bold26italic28bold27italic29bold28italic30bold29italic31bold30bold31italic32bold32italic33 OLE_LINK4bold33italic34bold34italic35bold35bold36italic36bold37italic37bold38italic38bold39italic40bold41italic41bold42italic42bold43italic43bold44italic44bold45italic45bold46italic46bold47italic47bold48italic48bold49italic49bold50italic50bold51aaaaaaaaazzNN\\gg!!iitt  %  YYee__ . . =   : : < ` ` l l s V V MM}}Q  !"#$%&'()*+,-./0123456789:;<>?=@ABCDEFGHJKILMNOPQRSTUVWXYZ[\]^_`azzzzzzzzzNNZZggppiitt  ##&  YYeeoo , , : : > : : ^ ` ` l l p p t V V MM[[}}Q@v]QQ>*urn:schemas-microsoft-com:office:smarttags PersonName HW  #%}%,HL**,,--/02356NQ**,,--/02356NQbNs0ist' .Ys ? ` u M_#}**,,--/02356NQ**,,--/02356NQ|T6})lg~D RȨ>68oԢZhVd&ܸ)({A[5h0AG y <jS)4-5(0l::v 1;xelh7$I~^`VWp`ab|mܰ`^`.^`.^`.^`. ^`OJQJo( ^`OJQJo( ^`OJQJo( ^`OJQJo(hh^h`. hh^h`OJQJo(h p^`B*o(ph Fig Name - ^`.pLp^p`L.@ @ ^@ `.^`.L^`L.^`.^`.PLP^P`L.^`o(. ^`hH. pLp^p`LhH. @ @ ^@ `hH. ^`hH. L^`LhH. ^`hH. ^`hH. PLP^P`LhH.h ^`hH.h ^`hH.h pLp^p`LhH.h @ @ ^@ `hH.h ^`hH.h L^`LhH.h ^`hH.h ^`hH.h PLP^P`LhH.^`.^`.pLp^p`L.@ @ ^@ `.^`.L^`L.^`.^`.PLP^P`L. <^` o i& J\Iu^&!^!hB"JU")j"R%&\8+s,--/T35)!7PP8?:,M@`@CBAEKsEBUF-GRI1J2JcNDPdY#Y}V[ ]]J%_Iaee6cfB>h/j]j)kVkc lvlmfopqlWtKubur|fi&}#@~["gBr6$)R<R#' d)8{#W,F NfSx@ 7lL | o|@z K(D+)(n*uxj8Bv:p!'=abjyzMN[\qs !.0hiqsst~  $' +.XYps^_`a % - . ; ?     9 : ; < _ ` q u  U V W X   _ ` a b LM\_ #|}Q@KKgKKz&P@UnknownGz Times New Roman5Symbol3& z Arial]  MS MinchoArial Unicode MS5& zaTahoma?5 z Courier New"1Hhg{&g{&D &D &nnx4d   2qHX ?-2_C:\documents and settings\jannis\application data\microsoft\templates\BMJ Templates\article.dot~The Impact of a Community-Oriented Problem-Based Learning Curriculum Reform on the Quality of Primary Care Delivered by Graduapplouffe Administrator`                Oh+'0 ,@LXl    The Impact of a Community-Oriented Problem-Based Learning Curriculum Reform on the Quality of Primary Care Delivered by Gradua pplouffe article.dotAdministrator5Microsoft Office Word@bn@bn@.D՜.+,D՜.+,l hp  Kirisq&   The Impact of a Community-Oriented Problem-Based Learning Curriculum Reform on the Quality of Primary Care Delivered by Gradua Titel@@4_AdHocReviewCycleID_EmailSubject _AuthorEmail_AuthorEmailDisplayName_ReviewingToolsShownOnceaQMessage from BMJrobyn.tamblyn@mcgill.caDr.Robyn Tamblyn  !"#$%&'()*+,-./0123456789:;<=>?@ACDEFGHIJKLMOPQRSTUVWXYZ[\]^_`abcdefghijklmnopqrstuvwxyz{|}~Root Entry F#Data B1TableNWordDocument4SummaryInformation(DocumentSummaryInformation8CompObjq  FMicrosoft Office Word-Dokument MSWordDocWord.Document.89q